Sermorelin: Instructions

Sermorelin is a peptide secretagogue – a substance that promotes the increased production of a hormone, in this case, somatotropin (growth hormone) from the pituitary gland. The body uses sermorelin in the same way it uses growth hormone-releasing hormone (GHRH), a chemical that the hypothalamus sends to the pituitary gland to stimulate GH secretion. In this report, we provide detailed sermorelin instructions for daily use by adults diagnosed with growth hormone deficiency.

The body uses sermorelin to enhance growth hormone secretion. Some people only need to use sermorelin acetate for six to twelve months until their pituitary gland reaches optimum production. By engaging in regular exercise, reducing stress, and getting enough sleep each night, growth hormone production could remain at a normal state. However, when actions for improving lifestyle habits to ensure optimum GH secretion are not in place, or if they do not work, it is also possible to remain on sermorelin indefinitely with virtually no risk of adverse effects.

Other individuals use sermorelin in conjunction with HGH therapy to stimulate natural growth hormone production while directly increasing it with human growth hormone treatment. The benefit of this is that it often shortens the duration or lessens the required dosage of HGH therapy.

*The sermorelin instructions provided are for daily adult use to treat growth hormone deficiency.


Sermorelin is a secretagogue that contains the first 29 amino acids found in growth hormone-releasing hormone. Although GHRH contains 44 amino acid residues, only the 29 found in sermorelin are necessary to stimulate GH production.

Unlike HGH, which binds to growth hormone receptors throughout the body, sermorelin does not influence these cells. The only function of sermorelin is to stimulate the somatotrophs (cells in the anterior pituitary gland) to produce and secrete somatotropin (GH).

Because sermorelin works on the somatotrophs, it promotes the natural pulsatile release of growth hormone into the bloodstream. Since the majority of GH production and functions occur at night, you will notice that sermorelin instructions are often for nighttime use. However, some people may be directed to administer sermorelin in the morning.

When injecting sermorelin at night, you provide the body with an increased supply of growth hormone to carry out the following functions that occur while you sleep:

  • Metabolic processing of food
  • Fat burning for added weight loss
  • Muscle building and repair
  • Bone strengthening
  • Processing of the day’s activities by the brain
  • Short-term storage of new information
  • Long-term memory storage
  • Strengthening of the immune system
  • Tissue repair
  • Collagen and elastin production
  • Cellular regeneration
  • Better sleep and more energy during the day

Sermorelin only helps adults whose bodies are not producing enough growth hormone. If your body currently produces enough GH, sermorelin will have no effect on increasing secretion levels.

*Sermorelin instructions are typically for nighttime use to best mimic natural growth hormone production and secretion.

Administering Sermorelin

As we begin our review of sermorelin instructions, it is essential to point out that the administration of this medication is by injection. Sermorelin is not available as a pill, spray, or any other product. It must be injected under the skin so that it can properly enter the bloodstream and travel to the pituitary gland.

Instructions and essential information for administering Sermorelin injections are as follows:


Sermorelin is used to treat adults diagnosed with growth hormone deficiency. Some of the signs of GHD in adults are:

  • Weight gain
  • Lethargy or fatigue
  • Muscle or bone loss
  • Wrinkles and sagging skin
  • Insomnia
  • Frequent illness
  • Hair thinning or balding
  • Joint pains
  • Low libido
  • Impaired sexual functions
  • Forgetfulness
  • Poor concentration
  • Depression or other mood changes


Do not use sermorelin if you are allergic to any of its ingredients. Let your doctor know about any medications, vitamins, supplements, and other over-the-counter products you take. Tell the doctor about all medical conditions, including the following before using sermorelin:

  • Pregnancy, nursing, or wanting to become pregnant
  • Type 2 diabetes or insulin medication use
  • Any type of brain injury, disease, or tumor


Your doctor will determine your dosage of sermorelin, depending on your body’s needs. Take only the amount of sermorelin as prescribed by your doctor – more will not be better.


Store sermorelin in the refrigerator, not in the freezer or at room temperature. Keep sermorelin and all medications out of reach of children and pets. Discard unused sermorelin as directed in your city.


Familiarize yourself with the sermorelin instructions for use included with your medication and supplies. Please contact our clinic with any questions before proceeding with your first or any subsequent injections.

The best place to inject sermorelin at home is the abdomen, approximately one inch away from the belly button in all directions. Alternate sides of use each night – do not use the same injection site two days in a row. Sermorelin injection is subcutaneous, delivered right below the skin surface using small, insulin-sized needles.

Always dispose of all syringes and needles in the provided Sharps container.

Sermorelin treatment is customized for each person. Your doctor will provide all mixing, dosage, and injecting instructions.

As you prepare to mix the sermorelin, remember to always sterilize the tops of any vials with an alcohol wipe before proceeding. You will use a separate syringe to mix the solution that is different from the injecting syringes you receive. Fill the mixing syringe with air equal to the amount of diluent that you will withdraw to mix the sermorelin.

Insert the needle of the syringe containing the diluent through the sermorelin rubber stopper and point it to the side of the viral. The solution should slowly run down the side of the vial and not directly into the powder. Swirl the vial gently after you remove the needle and replace the cap – do not shake the vial as that may render the solution ineffective. Dispose of the capped needle and syringe in a Sharps container.

Do not use sermorelin if you see particles or discoloration in the vial after mixing. Discard any unused or expired medications as directed in your city.

To administer the sermorelin, take a fresh insulin syringe and needle and fill it with the prescribed dosage of medication. Use an alcohol swab the clean the injection site and let it air dry. Pinch an area of skin around the prepared injection site and insert the needle completely into the skin. Slowly push in the plunger, holding the needle in place for five seconds to allow all the medication to enter the body. Then, remove and recap the needle and discard it in the Sharps container.

If you miss administering a dose of sermorelin, use it as soon as possible. However, do not take two doses at one time. If it is close to your next dose, then skip it and resume your treatment as prescribed.

Drug Interactions

The following list of medications could interfere with sermorelin actions:

  • Insulin
  • Glucocorticoids (prednisone)
  • Muscarinic antagonists (atropine)
  • Cyclooxygenase inhibitors (aspirin, indomethacin)
  • Thyroid-lowering medications (propylthiouracil)
  • Somatostatin-containing medications or ones that release somatostatin (clonidine, levodopa)


Get immediate medical help if you develop signs of an allergic reaction to sermorelin acetate, such as:

  • Hives
  • Itching
  • Difficulty breathing
  • Swelling of the face, lips, tongue, throat, or mouth
  • Rash
  • Tightness in the chest

Do not share your sermorelin with another individual, and do not use sermorelin that was prescribed to someone else. If you have any questions about sermorelin instructions, please contact HGH Doctor.