Sermorelin: Side Effects

Unlike HGH therapy, which runs the slight risk of increasing growth hormone levels in the bloodstream too high, sermorelin, also known as sermorelin acetate, does not carry that concern. Sermorelin does not introduce an increased amount of growth hormone into the body. Instead, it prompts the pituitary gland to stimulate low GH production back to a more normalized state. That is why sermorelin side effects are lower than seen with human growth hormone treatment.

Adults can remain on sermorelin therapy long-term to treat growth hormone deficiency without the risk of unpleasant side effects. Sermorelin brings all the benefits of HGH therapy without the increased possibility of adverse reactions.


In this review, we look at both the most common as well as the least likely side effects that could occur from sermorelin use. The most likely of all sermorelin side effects is a reaction at the site of the injection. Some people may experience any of the following at the injection site:

  • Redness
  • Itching
  • Swelling
  • Sensitivity
  • Pain
  • Irritation

These reactions typically disappear on their own without any action. Most people also report that they soon stop having injection site reactions, especially as they get better adept at self-administration of their shots.

*The most likely sermorelin side effects are skin reactions at the injection site.

Common Side Effects of Sermorelin Acetate

It is relatively uncommon to hear about the side effects of sermorelin in adults. The pituitary gland increases the production output of growth hormone when it receives signals from sermorelin. However, the hypothalamus will not let secretion get out of hand. If the hypothalamus senses high levels of growth hormone, it will send somatostatin to the pituitary gland to slow production. The only thing sermorelin can do is increase growth hormone production when it is low. That is why sermorelin side effects are rare when using this medication as prescribed.

The most common side effects of sermorelin include:

  • Dizziness
  • Headache
  • Sleepiness
  • Nausea
  • Hives
  • Flushing (redness in the face or neck)
  • Hyperactivity
  • Swallowing difficulty
  • Vomiting
  • Pale skin
  • Tightness in chest
  • Taste changes

It is unknown whether sermorelin passes through breast milk. Do not use sermorelin if you are pregnant, nursing, or hoping to become pregnant.

Also, sermorelin acetate may interact with other medications, such as glucocorticoids, corticosteroids such as prednisone, insulin, cyclooxygenase inhibitors such as aspirin and indomethacin, and thyroid medications such as levothyroxine. Please let your doctor know any medications and supplements (including vitamins) that you use before starting treatment with sermorelin.

*Although listed as common sermorelin side effects, the list above is actually quite rare for most adults receiving this treatment to increase growth hormone levels.

Rare Side Effects

Some individuals may also be allergic to ingredients in sermorelin. That can lead to the development of hives, rashes, dizziness, itching, or even breathing difficulties. Please alert your doctor to all allergies before starting sermorelin therapy. If you notice any of these reactions, please seek medical help at once as allergic reactions could escalate.

Other signs of allergic reactions include:

  • Swelling of the mouth, tongue, lips, or face
  • Tightness in the chest

Your doctor will also need to know if you have any brain disorders (such as legions), or hypothyroidism. Increasing growth hormone levels can impact the thyroid and its hormone production.

As you can see, the risks involved with sermorelin usage are very slight. It is difficult for a person to overdose on sermorelin acetate. Please remember to keep all medications out of reach of children and pets.

For additional information about sermorelin side effects, please contact HGH Doctor hormone clinic. We are happy to address any concerns and answer any questions during a free consultation by phone.