Humatrope: Instructions

Humatrope HGH comes in 6, 12, and 24 mg HumatroPen injector devices as well as 5 mg vials. In this review, we provide generalized Humatrope instructions for use by adults diagnosed with growth hormone deficiency (GHD).

Whether you select the pen or vial option, you will receive the same, high-quality recombinant HGH medication – only the delivery method is different.

Humatrope by Eli Lilly is one of the leading brands of human growth hormones. Our hormone doctors regularly prescribe Humatrope to our clients.

What is the difference between Humatrope pens and vials?

The primary difference is convenience, as you will see in the Humatrope instructions below. Humatrope vials come with vials of diluent that you utilize with mixing syringes. The HumatroPen injector cartridges come with prefilled diluent syringes that are ready for use to mix the medication. Many adults like the simplicity of the injector pens.

*Humatrope instructions differ slightly depending on whether you are using HumatroPen injectors or vials – both contain the same high-quality HGH medication.


Humatrope is the brand name for Eli Lilly’s recombinant human growth hormone medication, which contains somatropin – the biologically identical version of somatotropin (growth hormone). Due to the bioidentical structure of Humatrope, the body readily accepts and puts it to work, binding it to growth hormone receptors.

Vials of Humatrope are the most affordable way to receive this brand of HGH. HumatroPen injectors are more expensive as they are pen systems that utilize convenient, replaceable cartridges.

As you will see by reading the Humatrope instructions listed below, the medication is easy to use. Humatrope can help men and women in the following ways:

  • Improving metabolism, weight loss, and energy
  • Enhancing sexual desire and performance
  • Stimulating cellular regeneration which benefits the muscles, skin, organs, and bones
  • Supporting sharp brain functions, memory, and focus
  • Improving emotional health while reducing stress and depression
  • Strengthening immunity and speeding healing


*By following the prescribed Humatrope instructions, men and women can improve the status of their health, appearance, and brain functions.


The Humatrope instructions below are essential to read and understand before proceeding with your first injection. Please contact HGH Doctor hormone clinic with any questions.

Humatrope HGH is safe to use when prescribed by a hormone specialist to treat adult GHD. Do not use Humatrope if it has not been prescribed for you. Never use another person’s HGH medication or give yours to someone else. Do not increase or decrease your dosage as that can lead to unwanted side effects or reduce the results. Dispose of all unused or expired medications as directed by the city in which you live.

Always check the expiration date of your HGH medication before each use and do not use it if it is expired. Also, check the appearance of the medicine. Do not use Humatrope if it appears cloudy, discolored, or contains any crystals or particles.

Here are the Humatrope instructions and information you need to know before starting treatment for GHD:


Humatrope is indicated for use by adults diagnosed with growth hormone deficiency, as a result of adult-onset or continuing effects of childhood-onset. Blood analysis and physical examination are required for diagnosing GHD. Symptoms of GHD in adults include, but are not limited to, the following:

  • Weight gain
  • Fatigue
  • Sleep disturbances
  • Muscle loss
  • Impaired memory and mental functions
  • Increased stress and anxiety
  • Depression
  • Bone loss (height shrinkage, joint pains)
  • Premature physical aging (wrinkles, sagging skin, thinning hair)
  • Sexual decline
  • Long-lasting or frequent illness
  • Slow recovery/healing


  • Serious complications resulting from open-heart or abdominal surgery, multiple system accidental trauma, or life-threatening breathing problems
  • Active malignancy (cancer) – must receive oncologist clearance to begin treatment
  • Allergies to ingredients in Humatrope, including somatropin, metacresol, glycerin
  • Diabetic retinal disease
  • Pregnant or nursing


The doctor will determine your dosage following blood analysis and physical examination using the level of deficiency, body composition, age, gender, and health.


Humatrope requires continual refrigeration, both before and after mixing. Do not store in the freezer or at room temperature. Keep Humatrope HGH and all medications away from children and pets.

Humatrope vials are good for use within 14 days. HumatroPen cartridges are good for use for up to 28 days.


Preparation of the Humatrope vials is as follows:

  • Remove and discard plastic caps from the Humatrope and diluent vials and wipe both tops with an alcohol swab
  • Attach a needle to a new syringe, remove the needle cover, and pull back the syringe plunger to fill the syringe with air equal to the diluent amount you will withdraw
  • Insert the syringe needle into the diluent vial, push down the plunger to empty the air into the vial, and then invert the vial, so the fluid covers the needle
  • Slowly pull back the plunger filling the syringe with the prescribed amount of diluent – remove any air bubbles before removing the needle from the vial – ensuring the correct amount of diluent is in the syringe
  • While holding the vial upright, remove the needle and insert it into the Humatrope vial, aiming the tip to the side of the wall
  • Slowly push in the plunger to let the diluent flow down the side of the vial until empty
  • Remove the needle, replace the cover, and discard the unit in the Sharps container
  • Gently swirl the Humatrope vial to mix the solution – do not shake
  • Write the date of mixing on the vial label – it is good for 14 days

Preparation of the HumatroPen systems is as follows:

  • Ensure that your cartridge strength match your HumatroPen device
  • Refer to the illustrated instructions that come with your particular device
  • You will use the accompanying diluent syringe to reconstitute the HGH powder in the provided cartridge
  • Upon transferring the diluent into the cartridge, gently move the cartridge up and down 10 times – do not shake the solution – let it rest for 3 minutes to continue mixing
  • Attach the cartridge to the pen following the provided illustrated instructions
  • Remove the paper tab from a new needle and push it straight unto the cartridge until secure
  • Remove the outer and inner needle caps, discarding the inner cap and setting aside the outer cap for later use
  • Remove excess air from a new cartridge (priming it for use) as directed in the instructions – only necessary the first time a new cartridge is used
  • Dial the correct dosage by turning the knob to the prescribed dose number – the knob will turn back if you go past the dosage

Proceeding with your injection:

  • Clean the area on your abdomen (one inch away from the belly button) with a sterile alcohol wipe and let air dry (alternate sides each day)
  • Pinch an area of skin around the sterilized site and insert the needle completely at a 90-degree angle
  • Push in the syringe plunger or injector button slowly and hold for 5 seconds to allow all the medication to enter the body then remove and recover the needle
  • Discard the complete needle and syringe used with the vial or detach and discard the pen needle in the Sharps container
  • Return Humatrope to the refrigerator for storage

Drug Interactions

Tell your doctor about ALL medications, including over-the-counter preparations and supplements before starting HGH therapy. The following medications require monitoring while using Humatrope HGH:

  • Seizure medications (anticonvulsants)
  • Cyclosporin (immunosuppressive)
  • Estrogen
  • Glucocorticoids
  • Gonadotrophin
  • Insulin (diabetes medications)
  • Thyroid hormones


Tell your doctor if you have any of the following conditions:

  • Diabetes
  • Sleep apnea
  • Thyroid disease or abnormal thyroid function
  • Pregnant, breastfeeding, or trying to become pregnant
  • Prior history of cancer or tumors
  • Kidney disease
  • On glucocorticoid medication

Contact your doctor immediately if you experience any of the following:

  • Allergic reactions to Humatrope such as difficulty breathing, swelling of the face, lips, eyes, or throat, hives, rash
  • Nausea or vomiting
  • Headache
  • Wheezing
  • Pale skin

Accidental injection of too much Humatrope

Report any side effects from Humatrope to your doctor, including edema, carpal tunnel syndrome, muscle, joint, or nerve pain, or high blood sugar. These side effects are rare, and the doctor may lower the dosage of HGH until they disappear. Do not change the dosage yourself.

Some people experience injection site pain, itching, swelling, irritation, or redness. These reactions are normal and clear up on their own. Alert the doctor if these issues are ongoing or worsen.

If you have any questions about these Humatrope instructions, please contact HGH Doctor hormone clinic.