Best HGH for Men Over 40: What Age to Start Therapy – The Definitive Guide

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Author :Dr. Jonathan McKennell
Editor :Henry Evans

Feeling less energetic, losing muscle mass, and decreased exercise performance were once considered inevitable parts of aging. Thanks to research that proves the crucial role the endocrine (hormone) system plays in men’s overall health, we now know that these “natural” signs of aging can be prevented with improved hormone levels. More and more, scientists discover that hormone deficiencies like low human growth hormone (HGH) levels and low testosterone are often to blame with the declines in physical virility seen with age.

Once a deficiency is diagnosed by a licensed healthcare professional, hormone replacement therapy (HRT) is often wildly successful in restoring the strength and exuberance of youth in men over 40. To help you better understand HGH, the role it plays in men’s bodies, and the possibilities of treatment with HGH therapy, here is the definitive guide to HGH for men over 40.

How Growth Hormone Supports Men’s Health Throughout Life

Main HGH functions in adult menAlthough many people commonly associate GH with children’s growth, the hormone actually does a lot more than that at all stages of life. Even adults require adequate levels of growth hormone to remain healthy.

Throughout life, HGH performs the following functions:

  • Signaling muscle growth/repair
  • Maintaining bone density
  • Health metabolization of fats and sugars
  • Body composition regulation

HGH Throughout the Stages of Male Development

Growth hormone plays important and distinct over time and throughout life. The amount of GH that the pituitary gland secretes fluctuates to serve the different needs of the body.

Here is a rundown of GH’s various roles as we age:

  • Prenatal/Infancy

The research shows that GH is needed for the healthy development of “nearly all” human tissues. Unaddressed GH deficits in babies can result in irreparable damage.

  • Childhood

Growth hormone levels in children continue to climb until puberty. Replacement therapy is often an option for children at this stage who are very short and who test low for HGH.

  • Puberty

In addition to fueling the substantial physical growth that occurs during puberty, GH also regulates sexual development through its interaction with the so-called “sex hormones”, estrogen, testosterone, and progesterone.

  • First Period of Involution

Growth Hormone Decline In Men Chart

The thymus, gland that produces HGH, shrinks with age. This has profound implications on the functioning of the immune and hormone systems. The shrinkage of the thymus is a major component of the overall aging process. Interestingly, replacement therapy using growth hormone in one study restored thymus function in aging patients.

Normal levels of HGH in young males and men over 40

Unfortunately, men often lose HGH over time. Take a look at the chart below that illustrates the steady decline of circulating GH levels in men as they age.

Whereas doctors and researchers once believed a decline in GH to be an unavoidable part of aging, we now know that multiple strategies can slow the decline of this important hormone and ensure a higher quality of life as people move through the years.


As we’ll discuss later, there are ways to reverse this downward trajectory of GH through hormone replacement therapy (HRT). The majority of men respond very well to treatment, offering readings of levels commensurate with those of healthy young adults. Read further to discover how effective HRT can be.

Causes of Low Growth Hormone Levels in Men Over 40-50

What happens when GH levels begin to decline

GH deficiency is often accompanied by a host of unwanted negative symptoms, including

  • Weight gain/fat accumulation (especially around the belly)
  • Muscle loss
  • Fatigue
  • Difficulty concentrating
  • Dry skin
  • High cholesterol

Getting out of the mental and physical rut that characteristic of a growth hormone deficiency. However, never lose hope. Read on to discover how to achieve higher GH levels safely and effectively.

Causes of Low Growth Hormone Levels in Aging Men

A number of factors contribute to declining GH levels. Some of them are:

  • Poor diet
  • High body mass index (BMI)
  • Exposure to chemicals/radiation
  • Genetic predisposition
  • Ambient air pollution
  • Cancer treatment
  • Certain medications
  • Lack of sleep

Maintaining healthy growth hormone levels requires patients to address these underlying risk factors to sustain their hormone levels over the long term. Even with replacement therapy, keeping circulating GH levels high often requires accompanying lifestyle adjustments such as eating healthier foods and ensuring plenty of time for sleep.

The Benefits Men Age 40-50 Can Expect from HGH Therapy

The Benefits Men Age 40-50 Can Expect from HGH Therapy

If your provider determines that you are an ideal candidate for replacement therapy, you can expect to notice the following benefits following treatment:

  • More energy. One of the most common complaints of men over 40 who have a GH deficiency is the chronic feeling of tiredness. The men who complete treatment overwhelmingly remark on how much “younger” they feel, meaning more vibrant and dynamic.
  • Better endurance. Men who participate in athletics usually notice an improvement in their cardiovascular performance – they can last longer at higher intensities than before treatment.
  • Less anxiety/depression. Mental health issues and low growth hormone often go hand-in-hand. Men who undergo replacement therapy report better mood and less anxiety.
  • Because each person responds uniquely to therapy, the only way to discover the benefits that await you, if you experience a growth hormone deficiency, is to try it yourself.

Causes of Low Growth Hormone Levels in Aging Men

HGH Replacement Options for Men Ages 40-50

The most effective method of HRT is through injection. Oral medications exist as well, but the effectiveness is not as well-proven as injectable forms of growth hormones. Several options exist for somatotropin, the generic name of synthetic growth hormone available in the US. Always source your GH from one of the handful of reputable, licensed, FDA-approved manufacturers.

The only way to guarantee the quality and purity of your HGH supplementation is to select a respected producer. Here are the best HGH Medications available in the US.

Optimal HGH Medications for Men Ages 40-50

Several manufacturers in the US supply the market with unadulterated, chemical-free HGH. We highly recommend the following brands of synthetic GH:

Injectable HGH supplements typically come in one of two forms: vials with preparation kits and “pens.” The vials come with mixing solutions, syringes, and instructions. Vials allow more flexibility in terms of dosages. The pens are more convenient to use and carry, with all the necessary pieces contained in one item. Men who travel often generally prefer the pens because of their portability and ease of use.

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How to Begin Your HGH Replacement Journey Today

If you are a man between 40 and 50 who has experienced a loss of energy, unwanted weight gain, or mental health issues, hormone replacement therapy with HGH could be what you need to feel like your old self.

For more information on replacement therapy and how it works, don’t hesitate to contact us. We’ll set up a free consultation with one of our experts to discuss all your concerns. We’re ready to get started on the necessary work to optimize your hormone levels for better today.